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When virtually all of the residents of Piedmont, New Mexico, are found dead after the return to Earth of a space satellite, the head of the US Air Force's Project Scoop declares an emergency. A group of eminent scientists led by Dr. Jeremy Stone scramble to a secure laboratory and try to first isolate the life form while determining why two people from Piedmont - an old alcoholic and a six-month-old baby - survived. The scientists methodically study the alien life form unaware that it has already mutated and presents a far greater danger in the lab, which is equipped with a nuclear self-destruct device designed to prevent the escape of dangerous biological agents..
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For Miranda Wells, moving to New York to live in Dragonwyck Manor with her rich cousin, Nicholas, seems like a dream. However, the situation gradually becomes nightmarish. She observes Nicholas' troubled relationship with his tenant farmers, as well as with his daughter, to whom Miranda serves as governess. Her relationship with Nicholas intensifies after his wife dies, but his mental imbalance threatens any hope of happiness.
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Virginia Cunningham is confused upon finding herself in a mental hospital, with no memory of her arrival at the institution. Tormented by delusions and unable to even recognize her husband, Robert, she is treated by Dr. Mark Kik, who is determined to get to the root of her mental illness. As her treatment progresses, flashbacks depict events in Virginia's life that may have contributed to her instability.