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Synopsis

When a strain of mad cow disease mutated into "mad person disease" that became "mad zombie disease", which overran the entire United States (with the infection presumably spreading to the rest of the world), turning many Americans into vicious zombies. Survivors of the zombie epidemic have learned that growing attached to other survivors is not advisable because they could die at any moment, so many have taken to using their city of origin as nicknames. Lonely college student Columbus (Jesse Eisenberg) is making his way from his college dorm in Austin, Texas, to Columbus, Ohio, to see whether his parents are still alive. He encounters Tallahassee (Woody Harrelson), another survivor, who is particularly aggressive when killing zombies. Though he does not appear to be friendly, Tallahassee reluctantly allows Columbus to travel with him. Tallahassee mentions he misses his puppy, "Buck" that was killed by zombies, as well as his addiction to Twinkies, which he actively tries to find.
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