Suggestions by @user_289535

Joaquin Phoenix

as Cesare Borgia in Assassins's Creed: Brotherhood

Scarlett Johansson

as Lucy Stillman in Assassins's Creed: Brotherhood

Emily Blunt

as Caterina Sforza in Assassins's Creed: Brotherhood

Robert De Niro

as Mario Auditore in Assassins's Creed: Brotherhood

Tom Hardy

as Bartolomeo d' Alviano in Assassins's Creed: Brotherhood

Jenna Ortega

as Claudia Auditore Da Firenze in Assassins's Creed: Brotherhood

Mark Strong

as La Volpe in Assassins's Creed: Brotherhood

Elizabeth Debicki

as Lucrezia Borgia in Assassins's Creed: Brotherhood

Brendan Fraser

as Rodrigo Borgia in Assassins's Creed: Brotherhood

Nicholas Hoult

as Desmond Miles in Assassins's Creed: Brotherhood

Oscar Isaac

as Cesare Borgia in Assassins's Creed: Brotherhood

Daniel Radcliffe

as Shaun Hastings in Assassins's Creed: Brotherhood

Daniel Day-Lewis

as Leonardo Da Vinci in Assassins's Creed: Brotherhood

Jude Law

as Machiavelli in Assassins's Creed: Brotherhood

Christian Bale

as Ezio Auditore da Firenze in Assassins's Creed: Brotherhood