Suggestions by @user_235190

Robert Pattinson

as Frank Jaeger in Metal Gear Solid TV Series (Big Boss Era)

Sean Bean

as Gene/Viper in Metal Gear Solid TV Series (Big Boss Era)

Elizabeth Olsen

as EVA in Metal Gear Solid TV Series (Big Boss Era)

Dolph Lundgren

as Colonel Volgin/The Man On Fire in Metal Gear Solid TV Series (Big Boss Era)

Brad Pitt

as Revolver Ocelot in Metal Gear Solid TV Series (Big Boss Era)

Will Poulter

as Young Revolver Ocelot in Metal Gear Solid TV Series (Big Boss Era)

Aaron Eckhart

as Roy Campbell in Metal Gear Solid TV Series (Big Boss Era)

Simu Liu

as Kazuhira Miller in Metal Gear Solid TV Series (Big Boss Era)

Hugh Jackman

as Venom Snake/Ahab in Metal Gear Solid TV Series (Big Boss Era)

Uma Thurman

as The Boss/The Joy in Metal Gear Solid TV Series (Big Boss Era)

Hugh Jackman

as Naked Snake/Big Boss in Metal Gear Solid TV Series (Big Boss Era)

Hideo Kojima

as Producer in Metal Gear Solid TV Series (Big Boss Era)

David Hayter

as Writer in Metal Gear Solid TV Series (Big Boss Era)

Jordan Vogt-Roberts

as Director in Metal Gear Solid TV Series (Big Boss Era)