Suggestions by @superbat

Tom Selleck

as Tony Stark in The Avengers: Earth's Mightiest Heroes (1983)

Dolph Lundgren

as Thor Odinson in The Avengers: Earth's Mightiest Heroes (1983)

Dabney Coleman

as J. Jonah Jameson in Spider-Man (1983)

Robert Downey Jr.

as Spiderman in MCU 80s

John Cusack

as Spiderman in MCU 80s

Denis Leary

as Scott Lang in MCU 80s

Rachel McAdams

as Mrs. Eleanor Little in Stuart Little (2019)

John Krasinski

as Mr. Frederick Little in Stuart Little (2019)

Adam Driver

as Shadow the Hedgehog in Sonic the Hedgehog 4 (2026)

Sabrina Carpenter

as Amy Rose in Sonic the Hedgehog 3 (2024)

R. Lee Ermey

as J. Jonah Jameson in Spider-Man (1983)

Nathalie Emmanuel

as Ororo Munroe in Spider-Man (2011-2021) (TV Series)

Diane Lane

as Mary Jane Watson in Spider-Man (1983)

Jack Nicholson

as Norman Osborn in Spider-Man (1983)

Kelly Preston

as Mary Jane Watson in Spider-Man (1983)

Diane Lane

as Mary Jane Watson in Spider-Man (1983)

Elisabeth Shue

as Gwen Stacy in Spider-Man (1983)

Johnny Depp

as Harry Osborn in Spider-Man (1983)

Michael J. Fox

as Peter Parker in Spider-Man (1983)

John Travolta

as Wade Wilson in Wolverine Origins (1982)