Suggestions by @skytalk

Clint Mansell

as Composer in The Plague (2003)

Haley Joel Osment

as Ben in The Plague (2003)

Jon Brion

as Composer in Father Mother Sister Brother (2005)

Michel Gondry

as Director in Father Mother Sister Brother (2005)

Kenneth Lonergan

as Director in Father Mother Sister Brother (2005)

Joan Allen

as Emily in Father Mother Sister Brother (2005)

Sissy Spacek

as Timothea in Father Mother Sister Brother (2005)

Angela Lansbury

as Madame Gautier in Father Mother Sister Brother (2005)

Eva Mendes

as Skye in Father Mother Sister Brother (2005)

Jason Patric

as Jeff in Father Mother Sister Brother (2005)

Keanu Reeves

as Jeff in Father Mother Sister Brother (2005)

Josh Hartnett

as Anthony in Weapons (2005)

James Franco

as Anthony in Weapons (2005)

Jim Carrey

as Jeff in Father Mother Sister Brother (2005)

Cloris Leachman

as Mother in Father Mother Sister Brother (2005)

Nastassja Kinski

as Lilith in Father Mother Sister Brother (2005)

Ludacris

as Billy in Father Mother Sister Brother (2005)

Elisabeth Shue

as Jeanette in Father Mother Sister Brother (2005)

Max von Sydow

as Father in Father Mother Sister Brother (2005)

Carter Burwell

as Composer in Father Mother Sister Brother (2005)