Suggestions by @skytalk

John C. Reilly

as Captain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient in Cloud Atlas (2028)

Lupita Nyong'o

as Native Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym in Cloud Atlas (2028)

Adrien Brody

as Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins in Cloud Atlas (2028)

Natalie Portman

as Young Ursula in Cloud Atlas (2002)

Nicolas Cage

as Adam Ewing / Poor Hotel Guest / Megan's Dad in Cloud Atlas (2002)

Keke Palmer

as Miro in Cloud Atlas (2002)

Michael Douglas

as Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins in Cloud Atlas (2002)

Julian Sands

as Haskell Moore's Dinner Guest 3 / Jarvis Hoggins in Cloud Atlas (2002)

Isabella Rossellini

as Ms. Judd Look-a-like in Cloud Atlas (2002)

Jason Schwartzman

as Young Cavendish in Cloud Atlas (2002)

Josh Hartnett

as Young Cavendish in Cloud Atlas (2002)

Brady Corbet

as Zachry Relative in Cloud Atlas (2002)

Dakota Fanning

as Little Girl with Orison at Papa Song's / Catkin / Zachry Relative in Cloud Atlas (2002)

Howard Shore

as Composer in Cloud Atlas (2002)

Harry Dean Stanton

as Old Salty Dog / Mr. Meeks / Prescient 1 in Cloud Atlas (2002)

Matt Dillon

as Rufus Sixsmith (1936) / Rufus Sixsmith (1973) / Nurse James / Archivist Park in Cloud Atlas (2002)

Matthew Modine

as Union Spy in Cloud Atlas (2002)

Jonathan Hernandez

as Javier Gomez / Jonas / Zachry's Older Nephew in Cloud Atlas (2002)

James Remar

as Mr. Boerhaave / Guard / Leary the Healer in Cloud Atlas (2002)

Tony Goldwyn

as Haskell Moore's Dinner Guest 1 / Musician / Felix Finch / Lascivious Businessman in Cloud Atlas (2002)