Suggestions by @siddarthsid

Bea Arthur

as Magda in There's Something About Mary (1978)

Burt Reynolds

as Pat Healy in There's Something About Mary (1978)

Michael Rooker

as Police Captain in Se7en (2005)

Zoe Saldaña

as Tracy Mills in Se7en (2005)

Philip Seymour Hoffman

as John Doe in Se7en (2005)

Danny Glover

as William Somerset in Se7en (2005)

Ethan Hawke

as David Mills in Se7en (2005)

Dennis Franz

as Lt. Max Eckhardt in Batman (1989)

Anthony Zerbe

as Mayor Borg in Batman (1989)

Dick Miller

as Bob the Goon in Batman (1989)

Rene Russo

as Alicia Hunt in Batman (1989)

Telly Savalas

as Carl Grissom in Batman (1989)

Edward Woodward

as Alfred Pennyworth in Batman (1989)

Richard Roundtree

as Harvey Dent in Batman (1989)

Wilford Brimley

as Commissioner James Gordon in Batman (1989)

Daniel Stern

as Alexander Knox in Batman (1989)

Kim Cattrall

as Vicki Vale in Batman (1989)

Richard Gere

as Bruce Wayne in Batman (1989)

Dennis Hopper

as Jack Napier in Batman (1989)

Ncuti Gatwa

as Ruby Rhod in The Fifth Element (2022)