Suggestions by @rowenjackson

Julie Andrews

as Granny in Space Jam (Live-Action Remake)

Paul Julian

as Road Runner in Space Jam (Live-Action Remake)

Benedict Cumberbatch

as Wile E. Coyote in Space Jam (Live-Action Remake)

Nick Frost

as Opossum Brothers in Space Jam (Live-Action Remake)

Simon Pegg

as Mr. Weasel in Space Jam (Live-Action Remake)

Eric Bauza

as Tweety Bird in Space Jam (Live-Action Remake)

Bob Bergen

as Porky Pig in Space Jam (Live-Action Remake)

Jeff Bergman

as Sylvester in Space Jam (Live-Action Remake)

Zendaya

as Lola Bunny in Space Jam (Live-Action Remake)

Eric Bauza

as Daffy Duck in Space Jam (Live-Action Remake)

Tom Holland

as Bugs Bunny in Space Jam (Live-Action Remake)

Wayne Allwine

as Mickey in Looney Tunes: Crossovers

Tom Kenny

as SpongeBob in Looney Tunes: Crossovers

Andrew Sabiston

as Yoshi in Looney Tunes: Crossovers

Tony Rosato

as Luigi in Looney Tunes: Crossovers

Walker Boone

as Mario in Looney Tunes: Crossovers

Kelly Sheridan

as Starlight in Looney Tunes: Crossovers

Brendan Fraser

as DJ Drake in Looney Tunes: Crossovers

June Foray

as Miss Prissy in Looney Tunes: Crossovers

Tress MacNeille

as Penelope Pussycat in Looney Tunes: Crossovers