Suggestions by @richman
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Michael Douglas
as Batman in Richman’s: Batman the Movie (1986)

Grand Moff Tarkin
as Christopher Lee in What if this actor played

Albus Dumbledore
as Anthony Hopkins in What if this actor played

Alfred Pennyworth
as Anthony Hopkins in What if this actor played

Baron Vladimir Harkonnen
as Chris Cooper in What if this actor played

Lionel Luthor
as Chris Cooper in What if this actor played

Wolverine (James "Logan" Howlett)
as Tom Hardy in What if this actor played

Deathstroke (Slade Wilson)
as Tom Hardy in What if this actor played

Martian Manhunter
as Djimon Hounsou in What if this actor played

John Constantine
as Charlie Hunnam in What if this actor played

Green Arrow (Oliver Queen)
as Charlie Hunnam in What if this actor played

The Evil Queen
as Angelina Jolie in What if this actor played

Silver Sable
as Angelina Jolie in What if this actor played

Two-Face (Harvey Dent)
as Sharlto Copley in What if this actor played

Springtrap (William Afton)
as Steve Buscemi in What if this actor played

Carmine Falcone
as Steve Buscemi in What if this actor played

Talia al Ghul
as Sofia Boutella in What if this actor played

Brainiac (Vril Dox)
as Benedict Cumberbatch in What if this actor played

Lord Voldemort
as Benedict Cumberbatch in What if this actor played

Nick Fury Jr.
as Kevin Costner in What if this actor played