Suggestions by @milesyeargain

Debbie Reynolds

as Aunt May Parker in Spider-Man (1992)

Gregory Peck

as Uncle Ben Parker in Spider-Man (1992)

Adam Scott

as Harry Osbourne in Spider-Man (1992)

Alicia Witt

as Mary Jane Watson in Spider-Man (1992)

Al Pacino

as Green Goblin in Spider-Man (1992)

FAKE

as Spider-Man in Spider-Man (1992)

Stan Lee

as Cameo in Blade ll (1992)

Halle Berry

as Nyssa Damaskinos in Blade ll (1992)

Ron Perlman

as Dieter Reinhardt in Blade ll (1992)

Gene Hackman

as Abraham Whistler in Blade ll (1992)

Luke Perry

as Joshua Fromeyer / Scud in Blade ll (1992)

Stan Lee

as Cameo in Blade (1988)

Judd Nelson

as Quinn in Blade (1988)

Diana Ross

as Karen Jenson in Blade (1988)

Young Robert Downey Jr.

as Deacon Frost in Blade (1988)

Gene Hackman

as Abraham Whistler in Blade (1988)

Samuel L. Jackson (Blade)

as Blade in Blade ll (1992)

Susan Sarandon

as Mystique in X-Men (1990))

Michael J Fox

as Toad in X-Men (1990))

Random Actor/ Actress

as Sabertooth in X-Men (1990))