Suggestions by @lorog

Lola Bunny

as The Looney Leader in The Simpsons: The Final Chapter

Spoiler

as The Looney Leader in The Simpsons: The Final Chapter

Eddie Redmayne

as Professor John I.Q. Nerdelbaum Frink Jr. in The Simpsons: The Final Chapter

Wesley Snipes

as Sideshow Bob in The Simpsons: The Final Chapter

Jodie Foster

as Edna Krabappel in The Simpsons: The Final Chapter

Mahershala Ali

as Carl Carlson in The Simpsons: The Final Chapter

Tyler Perry

as Dr. Hibbert in The Simpsons: The Final Chapter

John Mulaney

as Lenny Leonard in The Simpsons: The Final Chapter

Hayden Christensen

as Waylon Smithers in The Simpsons: The Final Chapter

Clint Eastwood

as Mr. Burns in The Simpsons: The Final Chapter

Ben Mendelsohn

as Principal Skinner in The Simpsons: The Final Chapter

Jennifer Connelly

as Patty & Selma Bouvier in The Simpsons: The Final Chapter

Jackie Earle Haley

as Moe Szyslak in The Simpsons: The Final Chapter

Jay Lycurgo

as Millhouse Van Houten in The Simpsons: The Final Chapter

Jeremy Ray Taylor

as Ralph Wiggum in The Simpsons: The Final Chapter

Dan Fogler

as Chief Wiggum in The Simpsons: The Final Chapter

Ewan McGregor

as Ned Flanders in The Simpsons: The Final Chapter

Mckenna Grace

as Margaret Simpson in The Simpsons: The Final Chapter

Teagan Croft

as Lisa Simpson in The Simpsons: The Final Chapter

Diane Kruger

as Marge Simpson in The Simpsons: The Final Chapter