Suggestions by @lorog

Frankie Muniz

as Spider-Man in The Spectacular Spider-Man (2002)

Cillian Murphy

as Mysterio in The Friendly Neighborhood Spider-Man: Sinister

Frankie Muniz

as The Parker Boy in Ultimate X-Men (2001)

Spoiler

as The Parker Boy in Ultimate X-Men (2001)

Hugo Weaving

as Sabretooth in Ultimate X-Men (2001)

Brenda Song

as Jubilee in Ultimate X-Men (2001)

Emmy Rossum

as Shadowcat in Ultimate X-Men (2001)

Jake Gyllenhaal

as Iceman in Ultimate X-Men (2001)

Leonardo DiCaprio

as Angel in Ultimate X-Men (2001)

Naomie Harris

as Storm in Ultimate X-Men (2001)

Michael Clarke Duncan

as Beast in Ultimate X-Men (2001)

Bryce Dallas Howard

as Marvel Girl in Ultimate X-Men (2001)

Josh Brolin

as Wolverine in Ultimate X-Men (2001)

Brandon Routh

as Cyclops in Ultimate X-Men (2001)

Uma Thurman

as Mystique in Ultimate X-Men (2001)

Anthony Hopkins

as Dreykov in Black Widow & Hawkeye (1999)

Jeremy Irons

as Magneto in Ultimate X-Men (2001)

Cary-Hiroyuki Tagawa

as Professor X in Ultimate X-Men (2001)

Frank Welker

as H.E.R.B.I.E. in The Fantastic Four: The First Family (2000)

Stan Lee

as Willie Lumpkin in The Fantastic Four: The First Family (2000)