Suggestions by @jasleenfaydelarosa

Christopher Atkins

as Miles Jansen in Big Mouth (80s Teen Cast Genderswap)

Salma Hayek

as Mia Alvarez in Big Mouth (80s Teen Cast Genderswap)

BD Wong

as Alex in Big Mouth (80s Teen Cast Genderswap)

Lisa Bonet

as Deva Furtive-Oldman in Big Mouth (80s Teen Cast Genderswap)

Emilio Estevez

as Liam Ugfuglio Skumpy in Big Mouth (80s Teen Cast Genderswap)

Blair Underwood

as Mason Foreman-Greenwald in Big Mouth (80s Teen Cast Genderswap)

Kelly Hu

as Charlotte Lu in Big Mouth (80s Teen Cast Genderswap)

Lori Loughlin

as Nicole "Nicki" Arsenia Birch in Big Mouth (80s Teen Cast Genderswap)

Eric Stoltz

as Jesse Cobain Glaser in Big Mouth (80s Teen Cast Genderswap)

Jessica Lange

as Mrs. Morgan in The Weight Of Blood (80s)

Lauren Lindsey Donzis

as 2010s in Which Actress Should've Played Mary Anne Spier (Child) in Various Decades

Alyson Stoner

as 2000s in Which Actress Should've Played Mary Anne Spier (Child) in Various Decades

Quinn Cummings

as 70s in Which Actress Should've Played Mary Anne Spier (Child) in Various Decades

Angela Cartwright

as 60s in Which Actress Should've Played Mary Anne Spier (Child) in Various Decades

Shannen Doherty

as 80s in Which Actress Should've Played Mary Anne Spier (Child) in Various Decades

Kim Richards

as 70's in Which Actress Should've Played Stacey McGill (Child) in Various Decades

BD Wong

as Charles Lu in Big Mouth (80s Teen Cast)

Tom Cruise

as Nicholas Arsenio Birch in Big Mouth (80s Teen Cast)

Kelly Hu

as Ali in Big Mouth (80s Teen Cast)

Renee Murphy

as Samira in Big Mouth (80s Teen Cast)