Suggestions by @jamesthethinker

Christopher Eccleston

as Vincent Van Ghoul in Untitled Scooby Doo Spinoff Series

John Hoffman

as Writer in Truly devious

Rian Johnson

as Director in Truly devious

Perry Mason

as Attorney General in Building the ultimate fictional US Presidential Cabinet

Mrs. Puff

as Secretary of Transportation in Building the ultimate fictional US Presidential Cabinet

Lieutenant Dan

as Secretary of Veterans Affairs in Building the ultimate fictional US Presidential Cabinet

Captain America

as Secretary of Defense in Building the ultimate fictional US Presidential Cabinet

James P. "Sully" Sullivan

as Secretary of Energy in Building the ultimate fictional US Presidential Cabinet

Leslie Knope

as Vice President in Building the ultimate fictional US Presidential Cabinet

Mike Baxter (Last Man Standing)

as Secretary of Commerce in Building the ultimate fictional US Presidential Cabinet

Mon Mothma

as Secretary of State in Building the ultimate fictional US Presidential Cabinet

Pocahontas (Disney Character)

as Secretary of the Interior in Building the ultimate fictional US Presidential Cabinet

Leonard McCoy

as Secretary of Health and Human Services in Building the ultimate fictional US Presidential Cabinet

Cordell Walker

as Secretary of Homeland Security in Building the ultimate fictional US Presidential Cabinet

Villager

as Secretary of Agriculture in Building the ultimate fictional US Presidential Cabinet

George Bailey

as Secretary of Housing and Urban Development in Building the ultimate fictional US Presidential Cabinet

Jennifer Honey

as Secretary of Education in Building the ultimate fictional US Presidential Cabinet

Scrooge McDuck

as Secretary of the Treasury in Building the ultimate fictional US Presidential Cabinet

Hal Smith

as Santa Claus in Best Voices of Animated Characters

William Salyers

as Doctor Octopus in Best Voices of Animated Characters