Suggestions by @geekking97

Lance Henriksen

as Norman Osborn in Sam Raimi's Spider-Man Trilogy (1992-1997)

Miles Teller

as Harry Osborn in Alternative cast for the Spiderman movie

Emma Roberts

as Gwen Stacy in Alternative cast for the Spiderman movie

Emma Stone

as Mary Jane in Alternative cast for the Spiderman movie

Jason Isaacs

as Green Goblin in Alternative cast for the Spiderman movie

Larry Drake

as Otto Octavius/Doctor Octopus in James Cameron's Spider-Man (1996)

Bill Paxton

as Wrestling Announcer in James Cameron's Spider-Man (1996)

Arnold Schwarzenegger

as Crusher Hogan in James Cameron's Spider-Man (1996)

Bill Paxton

as Burglar in James Cameron's Spider-Man (1996)

Roy Scheider

as Uncle Ben in James Cameron's Spider-Man (1996)

Phyllis Diller

as Aunt May in James Cameron's Spider-Man (1996)

Danny Glover

as Robbie Robertson in James Cameron's Spider-Man (1996)

Phyllis Diller

as May Parker in Spider-Man (1996)

Octavia Spencer

as Check-In Girl in Spider-Man (1996)

Bruce Campbell

as Wrestling Announcer in Spider-Man (1996)

Brent Spiner

as Dr. Mendel Stromm in Spider-Man (1996)

Michael Douglas

as Green Goblin in Spider-Man (1992)

Dennis Quaid

as 2000s (Norman Osborn) in Actors Who Actors Who Could've or Could Play Norman Osborn & Harry Osborn

Aiden Gillen

as 2010s in Actors Who Could've or Could Play Doctor Doom

Aiden Gillen

as 2020s in Actors Who Could've or Could Play Doctor Doom