Suggestions by @devlinclements

Horton Hears a Who!

as David Spade in Roles That Actors / Actresses Were ALMOST Casted

Dr. Glickenstein (Igor)

as Christopher Lee in Roles That Actors / Actresses Were ALMOST Casted

King Malbert (Igor)

as Fred Willard in Roles That Actors / Actresses Were ALMOST Casted

Dr. Schadenfreude

as Eric Idle in Roles That Actors / Actresses Were ALMOST Casted

Brain (Igor)

as Matthew Broderick in Roles That Actors / Actresses Were ALMOST Casted

Eva (Igor)

as Jennifer Connelly in Roles That Actors / Actresses Were ALMOST Casted

Zipporah

as Jennifer Jason Leigh in Roles That Actors / Actresses Were ALMOST Casted

Aaron (The Prince of Egypt)

as Steve Buscemi in Roles That Actors / Actresses Were ALMOST Casted

Rameses

as Richard E. Grant in Roles That Actors / Actresses Were ALMOST Casted

Moses (The Prince of Egypt)

as Judd Nelson in Roles That Actors / Actresses Were ALMOST Casted

Sullivan (The Secret of NIMH)

as John Lithgow in Roles That Actors / Actresses Were ALMOST Casted

Justin (The Secret of NIMH)

as Danny DeVito in Roles That Actors / Actresses Were ALMOST Casted

Nicodemus

as Laurence Olivier in Roles That Actors / Actresses Were ALMOST Casted

Steele (Balto)

as Alec Baldwin in Roles That Actors / Actresses Were ALMOST Casted

Balto (Character)

as Crispin Glover in Roles That Actors / Actresses Were ALMOST Casted

Ms. Flint (Monsters, Inc.)

as Kathy Najimy in Roles That Actors / Actresses Were ALMOST Casted

Celia Mae

as Courteney Cox in Roles That Actors / Actresses Were ALMOST Casted

Randall Boggs

as Dennis Leary in Roles That Actors / Actresses Were ALMOST Casted

Mike Wazowski

as Jason Alexander in Roles That Actors / Actresses Were ALMOST Casted

Bruton (Dinosaur)

as Dean Cain in Roles That Actors / Actresses Were ALMOST Casted