Suggestions by @austindickey

Garrett Hedlund

as Gambit in X-Men (MCU)

Amanda Righetti

as Phoenix in X-Men (MCU)

Christian Kane

as Wolverine in X-Men (MCU)

Shelley Hennig

as Rogue in X-Men (MCU)

Joe Manganiello

as Sergei Kravinoff in Spiderman

Donnie Wahlberg

as Herman Schultz in Spiderman

JR Bourne

as Mac Gargan in Spiderman

Ben Foster

as Max Dillon in Spiderman

Helen Mirren

as Madame Web in Spiderman

Michael Chiklis

as Wilson Fisk in Spiderman

Daniel Cudmore

as Alexei Systevich in Spiderman

John Malkovich

as Adrian Toomes in Spiderman

Ioan Gruffudd

as Dr. Curt Connors in Spiderman

Matthew Gray Gubler

as Alistair Smythe in Spiderman

Jonathan Pryce

as Spencer Smythe in Spiderman

John Cena

as Flint Marko in Spiderman

Matthew Lillard

as Cletus Cassidy in Spiderman

John C. McGinley

as J Jonah Jameson in Spiderman

Bruce Campbell

as Quentin Beck in Spiderman

Adam Baldwin

as Nathan Summers in The X-Men