Suggestions by @acexavier

Rainn Wilson

as George Tarleton (M.O.D.O.K.) in All Superheroes and Villains (DC, Marvel, & Dark Horse Comics)

+2-0Score: +2

Alec Baldwin

as Perry White in Superman: Legacy

+1-1Score: 0

Henry Cavill

as Superman in Superman: Legacy

+1-4Score: -3

Tom Hiddleston

as The Eleventh Doctor in The NuWho: Alternative Casting

+1-0Score: +1

Tom Ellis

as The Tenth Doctor in The NuWho: Alternative Casting

+1-0Score: +1