When a student Jaime Santiago is a smart, kind, but overlooked high school student living in Brooklyn with his hardworking mother, his strict but protective father and his beloved uncle, the only one who suspects Jaime’s secret. After being bitten by a genetically altered spider during a science internship, Jaime develops incredible powers. Inspired by his family’s values, he becomes Spider-Man, quietly protecting the streets of New York. That hope is challenged when Alyosha Kravinoff, a ruthless new predator known as Kraven, arrives in the city seeking the ultimate hunt, Spider-Man is pushed beyond his limits. Jaime must learn what it truly means to be a hero before he becomes prey.