In New York, mysterious radioactive ooze has mutated four sewer turtles into talking, upright-walking, crime-fighting ninjas. The intrepid heroes -- Michelangelo, Donatello, Raphael and Leonardo -- are trained in the Ninjutsu arts by their rat sensei, Splinter. When a villainous gang of mutants shows up, its time for the Turtles, along with their new buddies April O'Neil and Casey Jones, to come out of their shells and fight.