Thumb Wrestling Federation centers around two rival thumb wrestling teams in the style of professional wrestling, including colorful characters and over-the-top emotions and antics. The protagonists, the Dexteras, wrestle against their rivals, the Sinistras, in the quest to win the coveted TWF title. The wrestling bouts are hosted by two thumb commentators, Dick Thompson and retired TWF wrestler Colonel Cossack. TWF originated as a television series before being licensed for toys, apparel, and collectibles.
Before its current state, the TWF was an honorable federation that was led by its older "wise thumbs," with TWF legend Newt Knuckle as its president. Everything was "thumbs up" in the TWF until a rookie thumb wrestler named Pageboy Skull came in and demanded a top spot in the TWF without working his way there or showing respect to any of the elder wrestlers, such as Newt Knuckle, Colonel Cossack (who is now a commentator for TWF), The Stash and Phineas D. Finger.
President Newt Knuckle swiftly denied Pageboy Skull his request, causing Pageboy Skull to revolt against the TWF. Pageboy Skull, who later rechristened himself Senator Skull, rebelled against the TWF and formed a group of renegades called the Evil Sinistras, who were determined to take over the TWF and possibly the world. In response, a group of honorable thumb wrestlers called the Mighty Dexteras formed to defend the TWF from the Sinistras.
