Spider-Man vs. Task Force X thrusts the web-slinger, Spider-Man (Peter Parker), into a high-stakes showdown with one of the world's most covert and ruthless government agencies, Task Force X, also known as the Suicide Squad. When the Squad is dispatched to apprehend Spider-Man, who they believe poses a threat to national security, the stage is set for an electrifying clash of heroism, anti-heroism, and villainy.
As Spider-Man finds himself hunted by an eclectic team of deadly operatives, including Deadshot, Killer Frost, and King Shark, he must rely on his wit, agility, and the unexpected aid of a few unlikely allies. With the fate of New York City hanging in the balance and powerful forces manipulating the strings behind the scenes, Spider-Man must prove that he is not the enemy and that even the most unlikely heroes can stand together in the face of danger.