Fan Casting Rob Lowe as Derek Shepherd in Recasting Grey’s Anatomy

phoebeb made this fan casting suggestion on February 15, 2021. What do you think? See below to cast your vote, or click here to see all fan casting suggestions for this role.

Rob Lowe as Derek Shepherd in Recasting Grey’s Anatomy

Rob LoweUnited States

60 years old
Robert Hepler "Rob" Lowe (born March 17, 1964) is an American actor. Lowe came to prominence after appearing in films such as The Outsiders, Oxford Blues, About Last Night..., and St. Elmo's Fire. ...
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Recasting Grey’s Anatomy

Recasting Grey’s Anatomy

Main Characters Only
by Shonda Rhimes
Grey’s Anatomy if it was made in 2020
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Rob Lowe is known for his roles in The Interview, Contact, and Sex Tape. He has been suggested by fans for 1,215 roles on myCast, including Horton The Elephant in Dr. Seuss' Horton Hears A Who! (2020s). Similar actors include Tom Cruise, Keanu Reeves, and Johnny Depp. Rob Lowe was suggested to play Derek Shepherd in Recasting Grey’s Anatomy by phoebeb. Other actors sugggested to play this role include Scott Eastwood and Clint Howard. Recasting Grey’s Anatomy has 22 roles, including Meredith Grey, Izzie Stevens, and Cristina Yang.

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