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Synopsis
While 8-year-old George's parents, Mr. and Mrs. Kranky, are out running errands, George's maternal grandmother bosses him around and bullies him. She scares George by saying that she likes to eat insects and he wonders briefly if she's a witch. To punish her for her regular abuse, George decides to make a magic medicine to replace her old one. He collects a variety of ingredients from around the family farm including deodorant and shampoo from the bathroom, floor polish from the laundry room, horseradish sauce and gin from the kitchen, animal medicines, engine oil and anti-freeze from the garage, and brown paint to mimic the colour of the original medicine.
After cooking the ingredients in the kitchen, George gives it as medicine to his grandmother, who grows as tall as the house, bursting through the roof. When his grandmother doesn't believe it was George who made her grow so tall, he proves it by feeding the medicine to one of his father's chickens, which grows ten times its original size. Mr. and Mrs. Kranky return home and can't believe their eyes when they see the fattest chicken ever and the grandmother. George's father grows very excited at the thought of rearing giant animals so that they can end world hunger, and his family will be rich and famous. He has George feed the medicine on the rest of the farm's animals, causing them to become giants as well. However, his grandmother begins complaining about being ignored and stuck in the roof, so Mr.Kranky hires a crane to remove her from the house. Her extreme height has her sleeping in the barn for the next few nights.
The following morning, Mr. Kranky is still excited about George's medicine and announces that he and George shall make gallons of it to sell to farmers around the world. George attempts to recreate it, but is unable to remember all the ingredients. The second medicine makes a chicken's legs grow extremely long, and the third elongates a chicken's neck to bizarre proportions. The fourth has the opposite effect of the first and makes animals shrink. George's grandmother, now even more angry she's sleeping in the barn, storms over and starts complaining loudly that she's once again sick of being ignored. She sees the cup of medicine in George's hand and mistakes it for tea. Much to his and Mrs. Kranky's horror, and Mr. Kranky's delight, she drinks the entire cup and shrinks so much that she vanishes completely. At first, Mrs. Kranky is shocked and confused about the sudden, and very strange, disappearance of her mother, but soon accepts that she was becoming a nuisance anyway. George reflects on the recent events, feeling as though they had granted him access to the edge of a magic world.