Set in the fictional crime-ridden Mexican American metropolis of Miracle City, El Tigre follows the adventures of Manny Rivera, a 13-year-old boy with superpowers trying to choose between being good or evil. Manny's father is a superhero known as White Pantera, and wants Manny to grow up to be good and fight evil. Manny's Grandpapi is a supervillain known as Puma Loco who thinks Manny should go to the dark side.