Arquette was born in Los Angeles,[1] the fourth of five children of Lewis Arquette, an actor and director,[2][3][4] and Brenda Olivia "Mardi" (née Nowak), a Jewish[5] actress, poet, theater operator, activist, acting teacher, and therapist. Lewis's family's surname was originally "Arcouet";[6] Lewis's father was comedian Cliff Arquette, who went by the stage name of Charley Weaver. Arquette was distantly related to American explorer Meriwether Lewis.[7][3] Actors Rosanna, Richmond, Patricia, and David Arquette are her siblings.
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